What Is VDR?

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VDR is a gene which codes for a protein that acts as a receptor for vitamin D which regulates bone growth and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with lower bone mineral density in prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by two components, and it is influenced by chromosomal location and binding preferences for specific hormones. Microarray studies in human cells reveal that over 100 genes contain VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online storage facility for data and documents relevant to legal, business, or other proceedings that have click to read restrictions on viewing and downloading. It is accessed via a central server as well as an extranet connection that is an Internet connection that has restricted access, to provide controlled log-on for set time periods during which users are able to access the data and documents.

VDRs are primarily used by investment banks and businesses involved in mergers and acquisitions. They need an efficient and secure platform to share information with investors or potential buyers in a clear and transparent manner, and the process of due diligence could require huge amounts of information. Life science companies also use VDRs for everything from clinical trial data to HIPAA documentation for compliance.

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